A Look at the ONE-D Protocol and Its Potential
At Clear Path Psychiatry, we’re dedicated to providing effective, science-backed care for individuals struggling with depression, especially those who haven’t found relief from traditional medication or therapy. A recent study introduces a groundbreaking possibility: completing an entire course of TMS therapy in just one day. Could this be the future of depression therapy? Let’s explore.
What Is the ONE-D Protocol?
ONE-D stands for Optimized, Neuroplastogen-Enhanced Depression treatment.It combines two key advancements:
- TMS delivery: 20 sessions of intermittent theta burst stimulation (iTBS) targeted at the brain’s left dorsolateral prefrontal cortex (DLPFC), spaced 27 minutes apart—all in a single day.
- Neuroplasticity enhancement: Single-dose use of two medications—d-cycloserine and lisdexamfetamine—that are thought to help the brain build new connections more efficiently in response to TMS.
This combination aims to maximize the brain’s ability to “rewire” itself—what scientists call neuroplasticity—in just one day of TMS therapy.
Who Was Studied?
The protocol was tested on 32 adults with treatment-resistant depression. Many had tried several antidepressants with no success, and about 40% had previously undergone TMS treatment. Most also experienced symptoms of anxiety.
What Were the Results?
- No serious side effects– All participants completed the one-day treatment safely.
- Delayed improvement– Most didn’t feel better right away, but saw steady progress over 4–6 weeks.
- Strong outcomes at 6 weeks:
- 90% showed significant improvements
- 74% achieved remission
- Long-lasting results – Many participants remained well at the 12-week check-in.
Why It Matters for Depression Therapy in Seattle
Standard TMS therapy involves 30–40 sessions over six to eight weeks, often requiring daily clinic visits. This can be difficult for people with limited time, mobility issues, or long travel distances.
The ONE-D protocol offers hope for:
- More accessible depression treatment options
- Faster results with fewer visits
- Flexibility for people with demanding schedules
- The possibility of at-home TMS therapy using portable equipment
As provider of TMS in Seattle, we believe innovative options like ONE-D could change the future of mental health care—especially for patients seeking depression therapy that works around their life, not the other way around.
Is ONE-D Right for You?
It’s important to note that ONE-D is still experimental. This was a small study without a placebo group, and the medications used were off-label. It may not be suitable for everyone, especially those needing immediate relief or who cannot take certain medications.
However, for patients open to a concentrated, research-based approach to TMS therapy, this protocol offers exciting potential.
Our Perspective at Clear Path Psychiatry
As a trusted provider of TMS therapy in Seattle, Clear Path Psychiatry is committed to staying at the forefront of emerging treatments. We’re closely following the data onONE-D and similar protocols and are ready to integrate new evidence-based tools as they become available.
If you or someone you know is struggling with treatment-resistant depression and looking for alternatives to traditional care, contact us today. We’ll help you explore your options and find a path to healing that fits your needs and schedule.
